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br Results A total of respondents
2023-10-18

Results A total of 126 respondents completed the survey (68.5% response rate), with at least 65% response rate from each of the four represented sectors (denominators represent the total constituent body of the organization or the total attendees of the meeting): PUC 24 out of 37 (65%), SPUNZA 33
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br STAR Methods br Acknowledgments We thank
2023-10-18

STAR★Methods Acknowledgments We thank Simcere Pharmaceuticals, Nanjing, China, for providing a rabbit anti-VEGF neutralizing monoclonal antibody. We thank Dr. Schlisio in the Ludwig Institute for Cancer Research, Karolinska Institute, for assistance with hypoxia assay. Y.C.’s laboratory is sup
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Due to its unique histological architecture and
2023-10-18

Due to its unique histological architecture and blood supply, the lung is one of the most susceptible organs under uncontrolled systemic inflammatory circumstance [16]. Several studies have reported the anti-inflammatory benefits of metformin in acute lung injury induced by lipopolysaccharide (LPS),
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APPL is highly expressed in pancreatic cells
2023-10-18

APPL1 is highly expressed in pancreatic β cells, but its levels are significantly decreased in several mouse models of obesity and diabetes, including HFD-induced obese mice and db/db mice [6], [73], suggesting that the dysregulation of APPL1 may be associated with malfunction of the pancreas in obe
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Adenosine receptors are proposed to play proangiogenic role
2023-10-18

Adenosine receptors are proposed to play proangiogenic role in vascular and immune AZ505 mg within microenvironment of hypoxic tissues to maintain tissue oxygenation in chronic ischemic condition [9]. Adenosine also stimulates the production of angiopoetin-1, VEGF and Interleukin-6 (IL6) via adenos
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br Results br Discussion The actin cytoskeleton is
2023-10-18

Results Discussion The Epinephrine HCl synthesis cytoskeleton is a highly attractive target for many bacterial toxins, owing to its role in activation and locomotion of immune cells, secretion of humoral response factors, and maintenance of protective barriers at the cellular (sub-membrane cy
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In this study an in vitro AChE inhibition assay combined
2023-10-18

In this study, an in vitro AChE inhibition assay combined with UF-HPLC-ESI-Q-TOF/MS method was developed for rapid screening and identification of AChEI from the roots of C. chinensis Franch. Five compounds was found with AChE inhibitory activity and identified by the on-line DAD-ESI-Q-TOF/MS compar
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Sulfo-NHS-LC-Biotin rs G allele was previously
2023-10-18

rs523349 G allele was previously associated with a decrease in the conversion rate of testosterone to DHT (Beesley et al., 2007). This SRDA52 variant may have a trend towards higher testosterone availability, which according to the US Food and Drug Administration is described as a teratogen of categ
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br Diabetes and obesity fit or fat sugar or
2023-10-18

Diabetes and obesity: fit or fat; sugar or not: the autophagic verdict Type 2 diabetes and obesity are among the most emerging health problems worldwide. The factors that are responsible for the establishment of diabetes include decreased AMG-458 production, rise in adiposity, and an increase in
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br Application of bamboo in the food and pharmaceutical
2023-10-17

Application of bamboo in the food and pharmaceutical industry For decades, the application of antioxidants in the food and pharmaceutical industry has been widespread. In the past, antioxidants were previously used to control oxidation and retard spoilage but today, many are used because of putat
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In a human intervention study blood GSH levels were evaluate
2023-10-17

In a human intervention study, blood GSH levels were evaluated over 6 wk in 18 male participants subjected to strenuous aerobic training and a dietary supplement of 1 g of WPI/kg of body mass per day. Blood GSH levels were significantly lower in those subjects who performed exercise that those who d
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It was deduced empirically that the helix direction of
2023-10-17

It was deduced empirically that the helix direction of the COOC torsion might relate to the sign of the peroxide Cotton effect. Huang reported ab initio calculation of the peroxide bond using MRDCI method and DZP basis set, but only the fragment CH3OOCH3 instead of full molecule was studied [19]. Si
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br Nanoparticle Conjugated Topoisomerase Inhibitors The safe
2023-10-17

Nanoparticle-Conjugated Topoisomerase Inhibitors The safety and efficacy of topotecan administered as LDM or MTD have been evaluated in several preclinical studies and a few clinical trials whose results showed that there can be significant adverse effects likely precluding its use in patients [5
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br Available treatment modalities for individuals with NAFLD
2023-10-17

Available treatment modalities for individuals with NAFLD There are several treatment modalities currently used or in clinical trials for individuals with NAFLD. The most widely recommended treatment is a lifestyle modification plan. As little as 5% weight loss has been shown to improve NASH hist
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The diversity of metabolic adaptations employed
2023-10-17

The diversity of metabolic adaptations employed by cancer cells in response to rapidly changing conditions, contributes to their biological aggressiveness and therapeutic resistance by enabling them to proliferate when nutrients are plentiful and to shift their resources to survival when nutrients a
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