• A localization of GK to both a

  2022-08-10

  

  A localization of GK to both a cytoplasmic and perinuclear area of normal rat pancreatic beta-cells was reported in 1996 (Noma et al., 1996), which changed on acute hyperglycemia to a more diffuse staining throughout the cytoplasm. The localization of GK within the nucleus was first reported by Mura

• The role of the ER EK variant which is associated

  2022-08-10

  

  The role of the ER22/23EK variant which is associated with relative resistance to GC, as shown by a reduction of transactivating capacity in vitro and less suppression of PHA-665752 levels after 1mg DST in vivo. Relative GC resistance associated with the ER22/23EK polymorphism might protect from the

• br STAR Methods br Acknowledgments We would like to

  2022-08-10

  

  STAR★Methods Acknowledgments We would like to thank Dr. Xiping Cheng for help with the immunohistochemistry staining, Qi Su for help with gene expression analysis, and Dr. Chaoying Liang at the UTSW Genomics Microarray Core facility for assistance on RNA-seq. W.-H.L. was supported by grant awa

• The fine interplay among post translational modifications an

  2022-08-10

  

  The fine interplay among post-translational modifications and intersection with other pathways, such as PI3K–AKT, has a crucial role in the regulation of GLI activity and in the generation of their repressor forms 40, 41, 42. In addition to β-TrCP, for example, other E3 ligases belonging to the real

• The regulatory effects of NADPH oxidase on ferroptosis

  2022-08-10

  

  The regulatory effects of NADPH oxidase on ferroptosis might also relate to neuroinflammation. Although ferroptosis can trigger inflammatory responses in the brain, neuroinflammation, in turn, can also modify ferroptosis. It has been reported that inflammatory conditions such as those found in neuro

• br Results br Discussion CD T cells

  2022-08-10

  

  Results Discussion CD8 T Cy5.5 maleimide (non-sulfonated) mg are important for immune control of many viral infections (Ehtisham et al., 1993, Kagi et al., 1994, Mullbacher et al., 1999, Walsh et al., 1994). CD8 T cells are essential for efficient clearance of MAV-1 from the lungs and for airw

• Disuflo Cy3 azide In Apicomplexan parasites such as Toxoplas

  2022-08-10

  

  In Apicomplexan parasites such as Toxoplasma gondii isoprenoids are biosynthesized through the DOXP/MEP pathway as illustrated in Scheme 2. In addition, T. gondii possesses a bifunctional FPPS/GGPPS (TgFPPS) that is able to catalyze the formation of both FPP and GGPP.5, 6 The FPPS gene appears to be

• Trifluoromethyl ketones and fluorophosphates were the first

  2022-08-10

  

  Trifluoromethyl ketones and fluorophosphates were the first generation FAAH inhibitors identified. They showed good in vitro FAAH inhibition potency, but most of them exhibited poor selectivity for FAAH over other serine hydrolases (such as the triacylglycerol hydrolase and the membrane-associated h

• Recent advances in imaging single protein mobility and

  2022-08-10

  

  Recent advances in imaging single protein mobility and organization in live organisms such as Drosophila larva motor nerve terminals have initiated this by providing a useful platform to investigate how the dynamic changes in the actomyosin network correlates with vesicle docking and fusion in vivo2

• br Material and methods br Results

  2022-08-09

  

  Material and methods Results Discussion It is challenging to discriminate between HIV monoinfection and HIV-1/2 dual infection in settings where both viruses co-exist, due to cross-reactivity in serological tests. Thus, the gold standard for detection of HIV-1/2 dual infection is through NA

• br Conflict of interest br Acknowledgements This work

  2022-08-09

  

  Conflict of interest Acknowledgements This work was funded by the University of Turin (ex60% 2014), World Wide Style Project (WWS; University of Turin/Fondazione CRT) and University of Florence (ex60% 2014). ACR and AP designed the study; AP, EB and IO conducted the literature search and analy

• Epigenetic drugs such as HDAC

  2022-08-09

  

  Epigenetic drugs, such as HDAC inhibitors, regulate gene expression by affecting the activity of histone or DNA modifying enzymes and their associated transcriptional response [141]. BET bromodomain protein inhibition is another epigenetic approach for blocking the Hedgehog pathway at the downstream

• br Transparency declaration br Acknowledgements br

  2022-08-09

  

  Transparency declaration Acknowledgements Hepatitis C Virus (HCV) infection represents a disease of significant global impact that afflicts around 170 million people worldwide., A small proportion of infected people clear the virus naturally, whilst the majority develop chronic hepatitis C

• br Conclusions br Introduction Astrocytes contribute to phys

  2022-08-09

  

  Conclusions Introduction Astrocytes contribute to physiological ctep function on many levels. They help maintain the physiological composition of the extracellular medium by, for instance, buffering potassium and uptake of neurotransmitters. They can also provide neurons with energy substrates

• Introduction Nicotinic acid niacin NA has

  2022-08-09

  

  Introduction Nicotinic dihydrochloride (niacin, NA) has been used in the treatment of dislipidemia and cardiovascular disease for almost 60years (Offermanns, 2006). Large clinical studies showed that niacin alone or in combination with LDL-lowering drugs improved cardiovascular outcomes (Canner et

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