• br Materials and methods br Results br Discussion br Disclos

  2022-05-24

  

  Materials and methods Results Discussion Disclosures Author contributions Acknowledgements Introduction Diabetes mellitus is one of the fastest growing chronic diseases worldwide, with an estimated prevalence of 382 million patients, of which about 90% have type 2 diabetes melli

• Pediatric cancers are fundamentally different from adult tum

  2022-05-23

  

  Pediatric cancers are fundamentally different from adult tumors and usually display a lower mutational burden and a faster growth rate. About 30% of all childhood malignancies are solid tumors and, in a majority of cases, respond well to chemotherapy. However, in particular in neuroblastoma the succ

• BCCA occlusion followed by reperfusion injury significantly

  2022-05-23

  

  BCCA occlusion, followed by reperfusion injury, significantly increased the brain AT1 and AT2 receptor expression in mice. Reports have demonstrated elevation of AT1 receptor expression in the cerebral Fluoxymesterone during ischemia [34,35]. The gene expression of brain AT2 receptor is increased i

• A oligomers increased ubiquitination of

  2022-05-23

  

  Aβ1-42 oligomers increased ubiquitination of GLT-1 in astrocytes. Previous studies found that astrocytic GLT-1 is internalized from the cell surface by ubiquitination of lysines located in the cytoplasmic C-terminus of the transporter (Gonzalez-Gonzalez et al., 2008, Martinez-Villarreal et al., 2012

• Na K ATPase adenosine triphosphate ATP and astrocytic glutam

  2022-05-23

  

  Na+/K+-ATPase, Senegenin and astrocytic glutamate transporters act together to maintain sodium and potassium gradients and the proper activities of EAAT1 and EAAT2 (Rose et al., 2009; Sheean et al., 2013); nevertheless, in present study, Na+/K+-ATPase activity was shown to be increased as from 24 h

• Caffeine Herein in consider of the

  2022-05-23

  

  Herein, in consider of the high similarity between GR HBP site and AR HBP site, we applied rational drug design strategy to develop AR/GR antagonists based on the chemical structures of antiandrogens and crystal structure of GR. The following bioassay identified Z19 as a dual AR/GR antagonist. Z19 i

• br The bile acid farnesoid X

  2022-05-23

  

  The “bile acid” farnesoid X receptor (FXR) The Farnesoid X Receptor (FXR) is a ligand-activated nuclear receptor belonging to the Nuclear Receptor superfamily of transcription factors exploiting various crucial functions in mammalian physiology, including reproduction, development and metabolism

• br FREE FATTY ACID RECEPTOR GPR br G PROTEIN

  2022-05-23

  

  FREE FATTY ACID RECEPTOR 1 (GPR40) G-PROTEIN-COUPLED RECEPTOR 120 CONCLUSION Free fatty Phosphatase Inhibitor Cocktail (2 Tubes, 100X) receptors whose natural ligands are identified as FFAs having various lengths have been reported. They act as novel nutrient sensing receptors independent o

• br Material and methods br

  2022-05-23

  

  Material and methods Acknowledgements and funding The authors thank Katharina Elsässer for technical support and Emma Esser for careful editing of the manuscript. We also thank Marcus Conrad for providing Liproxstatin-1 and advisory comments and discussion on the manuscript. This work was part

• The deduced amino acid sequences of all scIPPSs display

  2022-05-23

  

  The deduced amino PF-04620110 sequences of all scIPPSs display high similarity, and sequence alignments reveal seven conserved regions [2]. Regions II and VI contain the substrate-binding regions, with two characteristic aspartate-rich motifs (DDx(xx)xD; where x represents any amino acid residue). R

• In conclusion Factor Xa inhibitors edoxaban and rivaroxaban

  2022-05-23

  

  In conclusion, Factor Xa inhibitors (edoxaban and rivaroxaban) reduced PVs and SAN spontaneous activities in a concentration-dependent manner. FXa inhibitors may modulate occurrence of atrial fibrillation through PAR1 inhibition and INa-late reduction in PVs. Introduction Enzymes play crucial fu

• Introduction of a chloropyridine group onto

  2022-05-23

  

  Introduction of a chloropyridine group onto the fluoro derivative (→) leads to a similarly potent compound that exhibits a lower /, and as was observed with (), was rapidly cleared. However, the high clearance of () did not prevent the increase in the concentrations of FAAs even as its plasma levels

• EZH interaction with HADC and HDAC through the EED subunit

  2022-05-23

  

  EZH2 interaction with HADC1 and HDAC2 through the EED subunit is known to recruit histone deacetylases [113,114]. Given that PRC2-mediated repression of transcription may be partly dependent on the function of HDACs in specific cell contexts [115], the leukemia cell treatment with hydroxamic hexokin

• br Introduction Ovarian cancer patients have the

  2022-05-23

  

  Introduction Ovarian cancer patients have the highest mortality rate amongst patients with gynecologic cancers. The 10-year survival rate of ovarian cancer patients is cancer atr inhibitor with BRCA1/2 mutation [2]. Several studies have indicated the role of dysregulation of histone methylation

• Sometime ago we have described diamino triazines as

  2022-05-23

  

  Sometime ago we have described diamino-1,3,5-triazines as histamine H4R ligands,12, 13 and aryl derivatives of the 1,3,5-triazine, which attenuated inflammatory and nociceptive response in vivo in the rodent models of inflammation induced by indocid synthesis and zymosan. In this work we describe n

15806 records 429/1054 page Previous Next First page 上5页 426427428429430 下5页 Last page