• The following are the supplementary data related to this

  2022-03-18

  

  The following are the supplementary data related to this article. Authorship SLC and CGE performed the study conception and experimental design, wrote the paper and directed the activities of this work. ESM and JICA performed most of the degranulation assays, [Ca2+] measurements regarding to the

• Recently a receptor for nicotinic acid named

  2022-03-18

  

  Recently, a receptor for nicotinic acid, named GPR109A (also known as HM74a in man or PUMA-G in the mouse) has been identified (Lorenzen et al., 2001, Lorenzen et al., 2002, Soga et al., 2003, Tunaru et al., 2003, Wise et al., 2003). This receptor, a member of the 7 transmembrane G-protein coupled f

• The amino hydroxy methyl isoxazolepropionic acid AMPA recept

  2022-03-18

  

  The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic S63845 (AMPA) receptors are related ionotropic glutamate receptors (iGluRs) that mediate fast excitatory neurotransmission, and are also typically heteromeric ion channels, composed of GluA2 subunits in conjugation with GluA1, GluA3, or GluA4 subun

• In summary activated A AR exacerbated

  2022-03-18

  

  In summary, activated A2AR exacerbated the reverse transport function of endothelial EAATs through a direct or indirect pathway depending on PKA and glutamate levels in response to OGD in vitro, but A2AR inhibition quickly restored the normal transport function. Moreover, the key mechanisms by which

• Increasing evidence has shown that blockade of

  2022-03-18

  

  Increasing evidence has shown that blockade of glutamate uptake leads to aberrant behavioral consequences. For example, intracerebroventricular (i.c.v) injection or microinjection of the GLT-1 inhibitor, dihydrokainic GSA 10 (DHK), into the prefrontal cortex induces anhedonia [8,9]. Microinjection

• br Funding This work was supported by grants of

  2022-03-18

  

  Funding This work was supported by grants of the National Academy of Sciences of Ukraine within the programs “Molecular and cellular biotechnologies for medicine, industry and agriculture” (#35-2018), “Scientific Space Research for 2018-2022” (#19-2018), “Smart sensory devices of a new generation

• L Family Leguminosae widely distributed in tropical

  2022-03-17

  

  L. (Family Leguminosae) widely distributed in tropical and subtropical regions of the world. As a medicinal and edible plant, it is widely used in Asia, especially in China, Korea, Japan and India. It was first recorded in Shen Nong Ben Cao Jing (神农本草经), and was described having the effect of cleari

• Glucagon regulates the transition from hepatic glucose utili

  2022-03-17

  

  Glucagon regulates the transition from hepatic glucose utilisation in the absorptive state to glucagon production in the post-absorptive state by acute stimulation of glycogenolysis and inhibition of glycolysis [1]. An important component of this response is the phosphorylation of liver PFK2/FBPase2

• br Acknowledgments br Introduction Postmenopausal osteoporos

  2022-03-17

  

  Acknowledgments Introduction Postmenopausal osteoporosis, which is primarily caused by Cyanine 5-dCTP deficiency, has been a worldwide health problem and threatens postmenopausal women of all races. An estimated 80% of osteoporosis patients in the United States are women, and approximately 30

• Some clinical reports have suggested that

  2022-03-17

  

  Some clinical reports have suggested that galanin has a role in the neurobiology of mood disorders [[6], [7], [8], [9], [10]]. In behavioral studies, contradictory results have been reported [11,12]. For example, systemic administration of non-selective galanin receptor agonists, such as galmic [13]

• br Conclusions br Introduction Bioinformatics analysis shows

  2022-03-17

  

  Conclusions Introduction Bioinformatics analysis shows that there are about 300,000 G-rich sequences in human genome if searching with the consensus sequence (G3+N1-7G3+N1-7G3+N1-7G3+) [1], and their localizations are non-random. These G-rich sequences always localize in functional regions, su

• Bile acids BAs are critical

  2022-03-17

  

  Bile acids (BAs) are critical for facilitating the Erastin of dietary lipids and lipid-soluble vitamins in the intestines [6], [7]. At physiological levels, BAs function as signaling molecules and activate specific nuclear receptors [farnesoid X receptor (FXR), pregnane X receptor, and vitamin D rec

• However Gingrich and Hen reported that absence of the

  2022-03-17

  

  However, Gingrich and Hen reported that absence of the gene at all stages of ontogenesis of mice may interfere with the normal developmental program and/or the organism may undergo changes in other systems to compensate for gene absence (46). In addition, potentially altered maternal behavior of GPR

• While earlier reports on ferroptosis did

  2022-03-17

  

  While earlier reports on ferroptosis did not clarify mitochondrial damage and consequent death signaling in this paradigm of oxidative death, evidence from recent studies in neuronal systems strongly suggested a mechanistic link between enhanced lipid peroxide formation and loss of mitochondrial int

• Erythropoiesis involves the proliferation and differentiatio

  2022-03-17

  

  Erythropoiesis involves the proliferation and differentiation of hematopoietic stem GDC0449 to mature RBCs. This process is a tightly-regulated to adjust rates of RBC production based on physiologic need. Fas-mediated apoptosis is one mechanism that controls erythropoiesis. The role of Fas-signalin

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