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For CRM substrate binding to occur
2020-07-27
For CRM1-substrate binding to occur, the cargo molecule must have a leucine-rich NES (Wen et al., 1995, Fukuda et al., 1997). The NES for CRM1 contains hydrophobic amino acids, including isoleucine, leucine, methionine, phenylalanine, and valine (Kutay & Guttinger, 2005). A consensus motif for this
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br Introduction br Materials and methods br Results
2020-07-27
Introduction Materials and methods Results Discussion In the present study, etifoxine attenuated the anxiogenic-like behavioral and autonomic responses to i.c.v. injection of CRF in the rodent. Thus, in the open field, rats receiving CRF responded with an increased sensitivity to the str
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The Val Met functional polymorphism in the
2020-07-27
The Val(108/158)Met functional polymorphism in the COMT gene is located in exon 4 and results in replacing guanine with MHY1485 at position 472 in the long mRNA and at position 322 in the short mRNA. The polymorphism results in a substitution of valine with methionine in the membrane-bound long for
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Click chemistry is a kind of chemical synthesis to acquire
2020-07-27
Click chemistry is a kind of chemical synthesis to acquire various molecular product through small units quickly assembling. It has been applied to natural polymers or synthetic origins in many different architectures including linear (e.g., PEG, polysaccharides, proteins), branched (e.g., dendrimer
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This pathway appears to have importance in
2020-07-25
This pathway appears to have importance in epilepsy. DGKε(−/−) mice had significantly fewer motor seizure and epileptic events compared with DGKε(+/+) mice [18]. This could be explained by the fact that in the knockout mice a greater fraction of the SAG would be converted to 2-AG. 2-AG itself is kno
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br Conclusion Blueberry is becoming a worldwide crop with th
2020-07-25
Conclusion Blueberry is becoming a worldwide crop with the fastest rising consumer demand trends for its health benefits. However, the berry size is one of the key parameters for determining fruit quality and consumers’ preferences (Milic et al., 2018). Understanding the physiological and molecul
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In summary our data demonstrated a
2020-07-25
In summary, our data demonstrated a biological function of cpt1a gene from large yellow croaker. In particular, we indicated the effects of fasting on free carnitine status, CPT1 kinetics, and cpt1a mRNA expression in liver of large yellow croaker. During short-term fasting, the fish liver may have
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Unlike previous studies examining COMT
2020-07-25
Unlike previous studies examining COMT genotyping in healthy controls seeking to explain impulsive behaviors, this study sought to examine COMT genotypes in a large sample of individuals with varying levels of gambling behavior to determine whether COMT Tioconazole was associated with differences i
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Elevated homocysteine has been considered to be a risk
2020-07-25
Elevated homocysteine has been considered to be a risk factor for vascular dysfunction, vascular disease, and preeclampsia , . The methionine-homocysteine metabolism is responsible for supplying COMT with the methyl-group donor (-adenosyl methionine; SAM) necessary for 2-ME synthesis, and alteration
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Organ fibrosis is thought to be initiated by repeated or
2020-07-25
Organ fibrosis is thought to be initiated by repeated or chronic epithelial injury. The current belief is that damaged epithelial tivozanib induce an aberrant and unresolved wound repair process by activating fibroblasts via various profibrotic cues. Upon injury, epithelial cells activate the profib
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Interestingly selective ETA blockade increased cutaneous blo
2020-07-25
Interestingly, selective ETA blockade increased cutaneous blood flow as measured by laser Doppler fluxmetry. This is a measure of total blood flow in the different vessels in the skin including venules, CT-99021 as well as arterioles. This finding is in accordance with the previous demonstration th
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br Discussion The use of
2020-07-25
Discussion The use of carp primary cell cultures proved to be a valuable approach to evaluate the piscine immune response. A. hydrophila was a more potent stimulator of NO formation by carp leukocytes compared to commercial LPS often used for leukocyte stimulation (Mustafa and Olson, 1998, Chao e
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Therefore evaluation of base substances of alkali activated
2020-07-25
Therefore, evaluation of NS3694 synthesis substances of alkali-activated paste and alkali solution dosages have a remarkable impact on output products. Few research can be found in literature to assess GGBFS as a base materials of AAC. Even though less studies exists for serving RHA as base substanc
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In a recent report Yoshihara and colleagues
2020-07-25
In a recent report, Yoshihara and colleagues (2016) used transcriptomes derived from freshly isolated islets of 2-week-old neonatal, 6-week-old young adult, or 12-week-old adult mice to interrogate how maturation is regulated to acquire glucose responsiveness. The authors observed that estrogen-rela
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Recently experimentally exposed common carp
2020-07-25
Recently, experimentally-exposed common carp took up CLO from water and maintained a consistent concentration in the liver and blood plasma (Corcoran et al., 2014). Clotrimazole may influence other aquatic organisms. Survival and development of marine shrimp larvae (Palaemon serratus) were affected
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